6-[(2R)-2,3-dihydroxy-3-methylbutyl]-5,7-dimethoxy-2H-chromen-2-one

Name	6-[(2R)-2,3-dihydroxy-3-methylbutyl]-5,7-dimethoxy-2H-chromen-2-one
Synonyms	Toddaline Toddaloactone toddalolactone (+)-Toddalolactone 6-[(2R)-2,3-dihydroxy-3-methyl-butyl]-5,7-dimethoxy-coumarin 6-[(2R)-2,3-dihydroxy-3-methylbutyl]-5,7-dimethoxychromen-2-one 6-[(2R)-2,3-dihydroxy-3-methyl-butyl]-5,7-dimethoxy-chromen-2-one 6-(2,3-Dihydroxy-3-methylbutyl)-5,7-dimethoxy-2H-1-benzopyran-2-one 6-[(2R)-2,3-Dihydroxy-3-methylbutyl]-5,7-dimethoxy-2H-chromen-2-one 6-[(2R)-2,3-dihydroxy-3-methylbutyl]-5,7-dimethoxy-2H-chromen-2-one 2H-1-benzopyran-2-one, 6-[(2R)-2,3-dihydroxy-3-methylbutyl]-5,7-dimethoxy-
CAS	483-90-9
InChI	InChI=1/C16H20O6/c1-16(2,19)13(17)7-10-11(20-3)8-12-9(15(10)21-4)5-6-14(18)22-12/h5-6,8,13,17,19H,7H2,1-4H3/t13-/m1/s1

Molecular Formula	C16H20O6
Molar Mass	308.33
Density	1.269±0.06 g/cm3(Predicted)
Melting Point	269-270°C
Boling Point	530.0±50.0 °C(Predicted)
Specific Rotation(α)	(CHCl3)+55.9
Flash Point	195.5°C
Solubility	Soluble in chloroform, methanol
Vapor Presure	4.61E-12mmHg at 25°C
Appearance	White powder or crystal
pKa	14.39±0.20(Predicted)
Storage Condition	2-8℃
Refractive Index	1.568
MDL	MFCD11042251
Physical and Chemical Properties	Light yellow crystalline powder, soluble in methanol, derived from Zanthoxylum nitidum, Feilong palm blood.
In vitro study	Toddalolactone, a natural coumarin, inhibits PAI-1 activity by preventing the formation of a stable PAI-1/uPA covalent complex, suggesting that the inhibitory effect of Toddalolactone may be due to the interference of close contact between plasminogen activator and the active center of PAI-1.

overview	feilongzhang blood lactone, also known as nitidum, is a coumarin compound with a molecular formula of C16H20O6 and a molecular weight of 308.33. Zanthoxylum nitidum exists in Rutaceae (Rutaceae), Zanthoxylum bungeanum (Roxb.), Zanthoxylumnitidum(Roxb.)DC.), Zanthoxylum bungeanum (Zanthoxylumnitidumvar.fastuosum), and Toddaliaasiatica(L.)Lam.[PaulliniaasiaticaL.]).
biological activity	Toddalolactone,Toddalia the main component of asiatica, inhibits the activity of recombinant human plasminogen activator inhibitor -1 (PAI-1), IC50 is 37.31 μM.
target	TargetValue PAI-1 () 37.31 μM
Target	Value
PAI-1 ()	37.31 μM
in vitro study	Toddalolactone, a natural coumarin, inhibits PAI-1 activity by preventing the formation of a stable PAI-1/uPA covalent complex, suggesting that the inhibitory effect of Toddalolactone may be due to the interference of close contact between plasminogen activator and the active center of PAI-1.
chemical properties	light yellow crystalline powder, soluble in methanol, derived from Zanthoxylum nitidum, dragon palm blood.
use	nitidum has anti-inflammatory, analgesic, anti-cancer and antispasmodic effects. used for content determination/identification/pharmacological experiment, etc.

Last Update：2024-04-09 21:11:58

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6-[(2R)-2,3-dihydroxy-3-methylbutyl]-5,7-dimethoxy-2H-chromen-2-one Request for Quotation